{"id":4744,"date":"2024-11-27T09:26:31","date_gmt":"2024-11-27T01:26:31","guid":{"rendered":"\/\/www.rushplease.com\/?p=4744"},"modified":"2024-11-27T09:28:32","modified_gmt":"2024-11-27T01:28:32","slug":"%e6%b0%b4%e6%b0%a7%e7%a8%b3%e5%ae%9a%e7%9a%84%e5%9b%ba%e4%bd%93%e7%82%94%e5%9f%ba%e9%94%8c%e8%af%95%e5%89%82%e7%9a%84%e5%90%88%e6%88%90%e4%b8%8e%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"\/\/www.rushplease.com\/archives\/4744","title":{"rendered":"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528"},"content":{"rendered":"<p><a href=\"\/\/www.rushplease.com\/\" target=\"_self\" rel=\"noopener\"><strong>\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242<\/strong><\/a>\u7684\u5408\u6210\u4e0e\u5e94\u7528<\/p>\n<p>\u53cc\u53d6\u4ee3\u7094\u70c3\u5728\u6750\u6599\u79d1\u5b66\u548c\u836f\u7269\u5316\u5b66\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\uff0c\u540c\u65f6\u4e5f\u662f\u5408\u6210\u542b\u6709\u591a\u5b98\u80fd\u56e2\u70ef\u70c3\u7684\u91cd\u8981\u524d\u4f53\uff0c\u4ee5\u7094\u57fa\u91d1\u5c5e\u8bd5\u5242\u4e3a\u539f\u6599\u4e0e\u4e0d\u540c\u4eb2\u7535\u8bd5\u5242\u53cd\u5e94\u662f\u5f97\u5230\u591a\u53d6\u4ee3\u7094\u70c3\u7684\u4e3b\u8981\u65b9\u6cd5\u4e4b\u4e00\u3002\u76ee\u524d\uff0c\u5df2\u6709\u591a\u7bc7\u6587\u732e\u62a5\u9053\u4e86\u901a\u8fc7\u82b3\u9999\uff08\u6742\uff09\u73af\u3001\u70ef\u4e19\u57fa\u548c\u82c4\u57fa\u5364\u4ee3\u7269\u5236\u5907\u5f97\u5230\u5bf9\u6c34\u6c27\u7a33\u5b9a\u7684\u6709\u673a\u91d1\u5c5e\u8bd5\u5242\uff0c\u5176\u4e2d\u6709\u673a\u950c\u8bd5\u5242\u5728\u9ad8\u901a\u91cf\u7b5b\u9009\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d\u5177\u6709\u5f88\u597d\u7684\u524d\u666f\uff0c\u56fa\u76f8\u7684Reformatsky\u70ef\u9187\u5316\u53cd\u5e94\u5df2\u7ecf\u80fd\u591f\u5f88\u597d\u5730\u5e94\u7528\u4e8e\u6709\u673a\u53cd\u5e94\u4e2d\u3002\u6b64\u5916\uff0c\u82b3\u9999\uff08\u6742\uff09\u73af\u950c\u8bd5\u5242\u56e0\u5728\u7a7a\u6c14\u4e2d\u53ef\u4ee5\u5b58\u5728\uff0c\u5728Co\u50ac\u5316\u7684\u5076\u8054\u53cd\u5e94\u4e2d\u4f7f\u7528\u5e7f\u6cdb\u3002\u6700\u8fd1\uff0c\u6765\u81ea\u5fb7\u56fd\u6155\u5c3c\u9ed1\u5927\u5b66\u7684Paul Knochel\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u7c7b\u65b0\u7684\u6c34\u6c27\u7a33\u5b9a\u7684\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\uff0c\u5e76\u4ee5\u6b64\u51fa\u53d1\u6210\u529f\u5408\u6210\u4e86\u53cc\u53d6\u4ee3\u7684\u7094\u70c3\u3002<\/p>\n<p>\u4f5c\u8005\u901a\u8fc7\u672b\u7aef\u7094\u4e0eTMPZnCl\u2022Mg(OPiv)2\uff083\uff0cTMP=2,2,6,6-\u56db\u7532\u57fa\u54cc\u5576\uff09\u5408\u6210\u4e86\u7094\u57fa\u950c\u8bd5\u5242\uff081\uff09\uff0c\u5bf9\u591a\u79cd\u5b98\u80fd\u56e2\u90fd\u5177\u6709\u5f88\u597d\u5730\u517c\u5bb9\u6027\u3002\u521d\u6b65\u7814\u7a76\u8868\u660e\uff0c\u4e09\u7532\u57fa\u7845\u57fa\u4e59\u7094\uff082a\uff09\u4e0eTMPZnOPiv\u2022LiCl\u53cd\u5e94\u53ef\u4ee5\u5f97\u5230\u7094\u57fa\u950c\u8bd5\u52421a\uff0c\u4f46\u5176\u7a33\u5b9a\u6027\u8f83\u5dee\uff08\u7a7a\u6c14\u4e2d\u653e\u7f6e4 h\u540e\u4ec5\u4fdd\u755944%\u7684\u6d3b\u6027\uff09\uff0c\u4ed6\u4eec\u731c\u6d4bLiCl\u7684\u5b58\u5728\u53ef\u80fd\u5bfc\u81f4\u950c\u8bd5\u5242\u7684\u7a33\u5b9a\u6027\u8f83\u5dee\u3002\u968f\u540e\u4ed6\u4eec\u4f7f\u7528\u82c4\u57fa\u683c\u6c0f\u8bd5\u5242\u4e0eTMPH\u5728THF\u4e2d\u53cd\u5e94\uff0c\u7136\u540e\u52a0\u5165Zn(OPiv)2\uff0c\u53ef\u4ee5\u5b9a\u91cf\u5f97\u5230TMPZnOPiv\uff083\uff09\uff0c3\u4e0e2a\u53cd\u5e94\u53ef\u4ee5\u5f97\u5230\u7094\u57fa\u950c\u8bd5\u52421a\uff0c\u5e76\u4e14\u5728\u7a7a\u6c14\u4e2d\u653e\u7f6e4 h\u540e\uff0c\u4ecd\u7136\u5f97\u523090%\u7684\u6536\u7387\uff08\u56fe1\uff09\u3002\u901a\u8fc7\u8fd9\u4e00\u65b9\u6cd5\uff0c\u4f5c\u8005\u53ef\u4ee5\u5236\u5907\u542b\u6709\u7fb0\u57fa\u3001\u6c30\u57fa\u3001\u916f\u57fa\u7b49\u5b98\u80fd\u56e2\u7684\u7094\u57fa\u950c\u8bd5\u5242\uff0c\u8fd9\u7c7b\u8bd5\u5242\u5728\u7a7a\u6c14\u4e2d\u653e\u7f6e4 h\u540e\u4ecd\u7136\u5177\u670943-90%\u7684\u53cd\u5e94\u6d3b\u6027\u3002<\/p>\n<p>\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u3002\u56fe\u7247\u6765\u6e90\uff1aAngew. Chem. Int. Ed.<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-4745\" src=\"\/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1688270266158.jpg\" width=\"800\" height=\"600\" srcset=\"\/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1688270266158.jpg 800w, \/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1688270266158-350x263.jpg 350w, \/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1688270266158-768x576.jpg 768w, \/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1688270266158-220x165.jpg 220w\" sizes=\"(max-width: 800px) 100vw, 800px\" title=\"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528\u63d2\u56fe\" alt=\"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528\u63d2\u56fe\" \/><\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u4ed6\u4eec\u5c06\u5236\u5907\u7684\u7094\u57fa\u950c\u8bd5\u5242\u5e94\u7528\u5230Negishi\u5076\u8054\u53cd\u5e94\u4e2d\u3002\u901a\u8fc7\u6761\u4ef6\u7b5b\u9009\uff0c\u4f5c\u8005\u6700\u7ec8\u786e\u5b9aPd(dba)2\u4e0eDavePhos\u914d\u4f53\u7ed3\u5408\u5177\u6709\u6700\u597d\u7684\u50ac\u5316\u6d3b\u6027\uff0c\u5728\u6b64\u6761\u4ef6\u4e0b\uff0c\u4e00\u7cfb\u5217\u7684\u82b3\u9999\uff08\u6742\uff09\u73af\u7898\u4ee3\u7269\u3001\u6eb4\u4ee3\u7269\u3001\u6c2f\u4ee3\u7269\u90fd\u80fd\u591f\u4e0e\u7094\u57fa\u950c\u8bd5\u5242\u53d1\u751f\u53cd\u5e94\u5f97\u5230\u76ee\u6807\u4ea7\u7269\uff1b\u6b64\u5916\uff0c\u916f\u57fa\u3001\u9170\u57fa\u3001\u7532\u6c27\u57fa\u3001\u6c30\u57fa\u3001\u4e8c\u7ea7\u80fa\u3001\u9170\u80fa\u7b49\u57fa\u56e2\u90fd\u5177\u6709\u826f\u597d\u7684\u517c\u5bb9\u6027\uff0c\u5e76\u4e14\u82b3\u9999\u6742\u73af\u4fee\u9970\u7684\u7094\u57fa\u950c\u8bd5\u5242\u53c2\u4e0e\u53cd\u5e94\u4e5f\u5177\u6709\u7406\u60f3\u7684\u6536\u7387\u3002<\/p>\n<p>\u7094\u57fa\u950c\u8bd5\u52421\u7684Negishi\u5076\u8054\u3002\u56fe\u7247\u6765\u6e90\uff1aAngew. Chem. Int. Ed.<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-4746\" src=\"\/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1730162440229-1.png\" width=\"345\" height=\"263\" srcset=\"\/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1730162440229-1.png 345w, \/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1730162440229-1-220x168.png 220w\" sizes=\"(max-width: 345px) 100vw, 345px\" title=\"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528\u63d2\u56fe1\" alt=\"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528\u63d2\u56fe1\" \/><\/p>\n<p>\u8be5\u7c7b\u7094\u57fa\u950c\u8bd5\u5242\u4e5f\u53ef\u4ee5\u53c2\u4e0e\u5230\u5176\u4ed6\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u5076\u8054\u53cd\u5e94\u4e2d\u3002\u7094\u57fa\u950c\u8bd5\u52421e\u4e0e\u786b\u4ee3\u7fa7\u9178\u916f7\u5728Pd\u50ac\u5316\u4e0b\u53ef\u4ee5\u5f97\u5230\u7094\u57fa\u916e8\uff1b1j\u4e0e\u70ef\u4e19\u57fa\u6eb49\u7ecf\u7531CuCN\u20222LiCl\u50ac\u5316\u53ef\u4ee5\u5f97\u5230\u70ef\u709410\uff1b1c\u53ef\u4ee5\u5bf9\u919b\u4eb2\u6838\u52a0\u6210\u5f97\u5230\u7094\u4e19\u57fa\u9187\u3002<\/p>\n<p>\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5176\u4ed6\u5076\u8054\u53cd\u5e94\u3002\u56fe\u7247\u6765\u6e90\uff1aAngew. Chem. Int. Ed.<\/p>\n<p>\u9664\u6b64\u4e4b\u5916\uff0c\u4ed6\u4eec\u53d1\u73b0\u7094\u57fa\u950c\u8bd5\u5242\u4e5f\u53ef\u4ee5\u53d1\u751fCu\u50ac\u5316\u7684Click\u53cd\u5e94\uff08CuAAC\uff09\uff0c\u533a\u57df\u9009\u62e9\u6027\u5730\u5f97\u52301,4-\u4e8c\u53d6\u4ee3\u4e09\u5511\uff08\u56fe4\uff09\u3002\u7094\u57fa\u950c\u8bd5\u52421\u53ef\u4ee5\u4e0e\u82b3\u57fa\u53e0\u6c2e\u5316\u7269\u6216\u8005\u539f\u4f4d\u4ea7\u751f\u7684\u82c4\u57fa\u53e0\u6c2e\u5316\u7269\uff08\u82c4\u57fa\u6eb4\u4e0eNaN3\u53cd\u5e94\u5236\u5907\uff09\u5728CuI\u50ac\u5316\u4e0b\u5f97\u5230\u4e09\u5511\u7684\u950c\u8bd5\u5242\uff0c\u4e0e\u4eb2\u7535\u8bd5\u5242\u5076\u8054\u5f97\u5230\u591a\u53d6\u4ee3\u76841,2,3-\u4e09\u5511\uff086a-d\uff09\u3002<\/p>\n<p>Cu\u50ac\u5316\u76841,3-\u5076\u6781\u73af\u52a0\u6210\u53cd\u5e94\u3002\u56fe\u7247\u6765\u6e90\uff1aAngew. Chem. Int. Ed.<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-4747\" src=\"\/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1711950358963-1.png\" width=\"603\" height=\"368\" srcset=\"\/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1711950358963-1.png 603w, \/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1711950358963-1-350x214.png 350w, \/\/www.rushplease.com\/wp-content\/uploads\/2024\/11\/1711950358963-1-220x134.png 220w\" sizes=\"(max-width: 603px) 100vw, 603px\" title=\"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528\u63d2\u56fe2\" alt=\"\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528\u63d2\u56fe2\" \/><\/p>\n<p>\u5728\u6b64\u57fa\u7840\u4e4b\u4e0a\uff0c\u4ed6\u4eec\u8fd8\u5c06\u8be5\u53cd\u5e94\u5e94\u7528\u5230\u5177\u6709\u6f5c\u5728\u6297\u80bf\u7624\u6d3b\u6027\u836f\u726918\u7684\u5408\u6210\u4e2d\uff0c\u5316\u5408\u726922\u4e0eNaN3\u53cd\u5e94\u539f\u4f4d\u5f97\u5230\u82c4\u57fa\u53e0\u6c2e\u5316\u7269\uff0c\u4e0e\u7094\u57fa\u950c\u8bd5\u52421d\u5076\u8054\u5f97\u5230\u5173\u952e\u4e09\u5511\u7c7b\u4e2d\u95f4\u4f5323\uff0c\u7ecf\u8fc7\u540e\u7eed\u53cd\u5e94\u5f97\u5230\u6700\u7ec8\u4ea7\u726918<\/p>\n<p>\u7fa7\u80fa\u4e09\u551118\u7684\u5408\u6210\u3002\u56fe\u7247\u6765\u6e90\uff1aAngew. Chem. Int. Ed.<\/p>\n<p>Paul Knochel\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u5408\u6210\u7094\u57fa\u950c\u8bd5\u5242\u7684\u65b0\u65b9\u6cd5\uff0c\u8be5\u8bd5\u5242\u5bf9\u6c34\u6c27\u5177\u6709\u826f\u597d\u7684\u7a33\u5b9a\u6027\u4ee5\u53ca\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\uff0c\u5e76\u53ef\u5e94\u7528\u4e8e\u4e0e\u591a\u79cd\u82b3\u57fa\u3001\u70f7\u57fa\u548c\u9170\u57fa\u7684\u5076\u8054\u53cd\u5e94\u3002\u8be5\u7c7b\u950c\u8bd5\u5242\u540c\u65f6\u4e5f\u53ef\u4ee5\u8fdb\u884cCu\u50ac\u5316\u76841,3-\u5076\u6781\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u5e76\u4e14\u5728\u53cd\u5e94\u4e2d\u4fdd\u7559C-Zn\u952e\u3002\u4ed6\u4eec\u901a\u8fc7Click\u53cd\u5e94\u8fd8\u53ef\u4ee5\u5f97\u5230\u836f\u7269\u5206\u5b5018\uff0c\u8be5\u8bd5\u5242\u5728\u836f\u7269\u5408\u6210\u4e2d\u5177\u6709\u5f88\u597d\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6c34\u6c27\u7a33\u5b9a\u7684\u56fa\u4f53\u7094\u57fa\u950c\u8bd5\u5242\u7684\u5408\u6210\u4e0e\u5e94\u7528 \u53cc\u53d6\u4ee3\u7094\u70c3\u5728\u6750\u6599\u79d1\u5b66\u548c\u836f\u7269\u5316\u5b66\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\uff0c\u540c\u65f6\u4e5f\u662f\u5408\u6210\u542b\u6709\u591a\u5b98\u80fd\u56e2\u70ef\u70c3\u7684\u91cd\u8981\u524d\u4f53\uff0c\u4ee5\u7094\u57fa\u91d1\u5c5e\u8bd5\u5242\u4e3a\u539f\u6599\u4e0e\u4e0d\u540c\u4eb2\u7535\u8bd5\u5242\u53cd\u5e94\u662f\u5f97\u5230\u591a\u53d6\u4ee3\u7094\u70c3\u7684\u4e3b\u8981\u65b9\u6cd5\u4e4b\u4e00\u3002&#8230; <\/p>\n","protected":false},"author":2,"featured_media":4745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"_links":{"self":[{"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/posts\/4744"}],"collection":[{"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/comments?post=4744"}],"version-history":[{"count":1,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/posts\/4744\/revisions"}],"predecessor-version":[{"id":4748,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/posts\/4744\/revisions\/4748"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/media\/4745"}],"wp:attachment":[{"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/media?parent=4744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/categories?post=4744"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.rushplease.com\/wp-json\/wp\/v2\/tags?post=4744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}